It's hard to be certain without seeing all the details of the question you propose asking, but I would say that there would have to be a fairly strong element of database-specific configuration for this to be on-topic here. To put it another way, it needs to be reasonably likely to be answerable here, and to require some knowledge specific to database professionals.
For example, questions about configuring a network to work well with database clustering technologies would likely be on-topic; general questions about configuring a corporate network that just happens to serve a database would probably be better suited to Server Fault. Or, for a non-business environment, Super User.
If you are confident your question is specific enough to Database Administration, by all means go ahead and ask it on the main site, after reviewing How do I ask a good question? in the Help Center.
Should it later become apparent that the question would be better on Server Fault or Super User, you can always flag it for a moderator to migrate (assuming it is on-topic at the destination).
Aaron Bertrand: Just to further clarify the last point, if you post the question and someone suggests it is better suited for a different site, please flag and wait for migration, rather than adding an identical question on the other site. Migration is much easier for the sites to deal with than identical duplicates.